Rome2Rio

La Crosse to Jacksonville buses

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Trip Overview

The average bus between La Crosse and Jacksonville takes 38h 55m and the fastest bus takes 32h 35m. The bus runs, on average, 5 times per week from La Crosse to Jacksonville. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

38h 55m
Duration
1,396 mi
Distance
$319
Average price
5 times a week
Frequency

La Crosse to Jacksonville bus times

Buses run 5 times a week between La Crosse and Jacksonville. The service departs La Crosse at 2:30 PM in the afternoon, which arrives into Jacksonville at 07:00:00. All services require a transfer at Milwaukee and take an average of 38h 55m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USAGreyhound USAFlixbus USA40h 30m • 3 changes

Departing Wednesday, November 11, 2026

  •  → 

    Arrives next day

    Jefferson LinesGreyhound USAGreyhound USAFlixbus USA32h 35m • 3 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USAGreyhound USAFlixbus USA40h 30m • 3 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USAGreyhound USAFlixbus USA40h 30m • 3 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USAGreyhound USAFlixbus USA40h 30m • 3 changes

Frequently asked questions

Want to know about travelling from La Crosse to Jacksonville? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from La Crosse to Jacksonville.ExpandLaunch map view
  • Distance: 1,395.7 mi
  • Duration: 38h 55m

What companies run services between La Crosse, WI, USA and Jacksonville, FL, USA?

You can take a bus from La Crosse to Jacksonville via Milwaukee, Milwaukee Intermodal Station, Chicago Bus Station, and Atlanta Bus Station in around 31h 5m.

Operators