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La Crosse to Louisville buses

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Trip Overview

The bus between La Crosse and Louisville takes 16h 25m. The bus runs, on average, 6 times per week from La Crosse to Louisville. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

16h 25m
Duration
594 mi
Distance
$153
Average price
6 times a week
Frequency

La Crosse to Louisville bus times

Buses run 6 times a week between La Crosse and Louisville. The service departs La Crosse at 2:30 PM in the afternoon, which arrives into Louisville at 06:55:00. All services require a transfer at Madison and take an average of 16h 25m. The schedules shown below are for the next available departures.

Departing Tuesday, November 3, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAGreyhound USAAmtrak Thruway16h 25m • 3 changes

Departing Wednesday, November 4, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAGreyhound USAAmtrak Thruway16h 25m • 3 changes

Departing Thursday, November 5, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAGreyhound USAAmtrak Thruway16h 25m • 3 changes

Departing Friday, November 6, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAGreyhound USAAmtrak Thruway16h 25m • 3 changes

Departing Saturday, November 7, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAGreyhound USAAmtrak Thruway16h 25m • 3 changes

Departing Sunday, November 8, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAGreyhound USAAmtrak Thruway16h 25m • 3 changes

Frequently asked questions

Want to know about travelling from La Crosse to Louisville? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from La Crosse to Louisville.ExpandLaunch map view
  • Distance: 593.7 mi
  • Duration: 16h 25m

What companies run services between La Crosse, WI, USA and Louisville, KY, USA?

You can take a bus from La Crosse to Louisville, KY via Madison, Chicago Bus Station, and Indianapolis Union Station in around 14h 30m.

Operators