The average bus between La Crosse and St. Louis takes 19h 56m and the fastest bus takes 16h 50m. The bus runs, on average, 6 times per week from La Crosse to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 6 times a week between La Crosse and St. Louis. The earliest departure is at 2:30 PM in the afternoon, and the last departure from La Crosse is at 2:30 PM which arrives into St. Louis at 3:40 PM. All services require a transfer at Milwaukee and take an average of 19h 56m. The schedules shown below are for the next available departures.
Want to know about travelling from La Crosse to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from La Crosse to St. Louis. However, there are services departing from La Crosse station and arriving at St. Louis station via Milwaukee. The journey, including transfers, takes approximately 19h 56m.
La Crosse to St. Louis bus services, operated by Jefferson Lines, depart from La Crosse station.
La Crosse to St. Louis bus services, operated by Jefferson Lines, arrive at St Louis Bus Station.
Book your La Crosse to St. Louis bus tickets online with Jefferson Lines, Greyhound USA and Flixbus USA.
The distance between La Crosse and St. Louis is 581.9 km. The road distance is 980 km.
You can take a bus from La Crosse to St Louis Bus Station via Milwaukee, Milwaukee Intermodal Station, and Chicago Bus Station in around 13h 20m.
