The average bus between La Jolla and Irvine takes 3h 58m and the fastest bus takes 3h. The bus service runs several times per day from La Jolla to Irvine. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between La Jolla and Irvine. The earliest departure is at 7:29 AM in the morning, and the last departure from La Jolla is at 10:00 PM which arrives into Irvine at 1:00 AM. All services require a transfer at Old Town Transit Center and take an average of 3h 58m. The schedules shown below are for the next available departures.


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3h 41m • 2 changesWant to know about travelling from La Jolla to Irvine? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from La Jolla to Irvine. However, there are services departing from Silverado St & Herschel Av station and arriving at Main-Harvard station via Old Town Transit Center station and Anaheim Regional Transportation Intermodal Center station. The journey, including transfers, takes approximately 3h 58m.
La Jolla to Irvine bus services, operated by San Diego Metro Transit, depart from Silverado St & Herschel Av station.
La Jolla to Irvine bus services, operated by OCTA, arrive at Main-Harvard station.
Book your La Jolla to Irvine bus tickets online with Omio.
The distance between La Jolla and Irvine is 104.7 km. The road distance is 125 km.
You can take a bus from Silverado St & Herschel Av to Main-Harvard via Old Town Transit Center, San Diego, Anaheim Regional Transportation Intermodal Center, and Artic - Dock 4 in around 4h 24m.