The average bus between La Jolla and Otay Mesa takes 3h 15m and the fastest bus takes 2h 6m. The bus service runs several times per day from La Jolla to Otay Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a day between La Jolla and Otay Mesa. The earliest departure is at 11:03 AM in the morning, and the last departure from La Jolla is at 11:00 PM which arrives into Otay Mesa at 5:55 AM. All services require a transfer at Old Town Transit Center and take an average of 3h 15m. The schedules shown below are for the next available departures.



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Arrives next day



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Want to know about travelling from La Jolla to Otay Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from La Jolla to Otay Mesa. However, there are services departing from La Jolla station and arriving at Otay Mesa station via Old Town Transit Center. The journey, including transfers, takes approximately 3h 15m.
La Jolla to Otay Mesa bus services, operated by San Diego Metro Transit, depart from Silverado St & Herschel Av station.
La Jolla to Otay Mesa bus services, operated by San Diego Metro Transit, arrive at Iris Avenue Transit Center station.
The distance between La Jolla and Otay Mesa is 41.4 km. The road distance is 62 km.
You can take a bus from Silverado St & Herschel Av to Otay Mesa Rd & Cactus Rd via Old Town Transit Center, San Diego Greyhound Bus Stop, San Ysidro Transit Center, and Iris Avenue Transit Center in around 2h 52m.