The average bus between La Mesa and Anaheim takes 3h 25m and the fastest bus takes 2h 42m. The bus service runs several times per day from La Mesa to Anaheim. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between La Mesa and Anaheim. The earliest departure is at 7:30 AM in the morning, and the last departure from La Mesa is at 10:19 PM which arrives into Anaheim at 10:15 AM. All services require a transfer at 12th & Imperial Station and take an average of 3h 25m. The schedules shown below are for the next available departures.

3h 27m • 1 change
3h 6m • 1 changeArrives next day

2h 50m • 1 change
2h 45m • 1 change
3h 6m • 1 changeArrives next day

2h 50m • 1 change
2h 45m • 1 change
2h 42m • 1 change
3h 27m • 1 change
3h 6m • 1 change
2h 45m • 1 change
2h 42m • 1 change
3h 27m • 1 change
3h 6m • 1 changeWant to know about travelling from La Mesa to Anaheim? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from La Mesa to Anaheim. However, there are services departing from La Mesa station and arriving at Anaheim station via Anaheim. The journey, including transfers, takes approximately 3h 25m.
La Mesa to Anaheim bus services, operated by San Diego Metro Transit, depart from San Diego station.
La Mesa to Anaheim bus services, operated by San Diego Metro Transit, arrive at Anaheim station.
The distance between La Mesa and Anaheim is 144.7 km. The road distance is 171 km.
Greyhound Mexico operates a bus from San Diego to Anaheim twice daily. Tickets cost $18–29 and the journey takes 2h 10m.