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La Mesa to Irvine buses

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Trip Overview

The average bus between La Mesa and Irvine takes 4h 24m and the fastest bus takes 3h 13m. The bus service runs several times per day from La Mesa to Irvine. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 24m
Duration
112 mi
Distance
$26
Average price
4 times a day
Frequency

La Mesa to Irvine bus times

Buses run 4 times a day between La Mesa and Irvine. The earliest departure is at 7:30 AM in the morning, and the last departure from La Mesa is at 10:19 PM which arrives into Irvine at 11:39 AM. All services require a transfer at Old Town Transit Center and take an average of 4h 24m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

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    Arrives next day

    San Diego Metro TransitFlixbus USAOCTA3h 13m • 2 changes

Departing Wednesday, November 11, 2026

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    San Diego Metro TransitFlixbus USAOCTA4h 14m • 2 changes
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    San Diego Metro TransitGreyhound USAOCTA3h 53m • 2 changes
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    San Diego Metro TransitFlixbus USAOCTA4h 53m • 2 changes
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    San Diego Metro TransitGreyhound USAOCTA3h 58m • 2 changes
  • Show more

Departing Thursday, November 12, 2026

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    San Diego Metro TransitFlixbus USAOCTA4h 14m • 2 changes
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    San Diego Metro TransitGreyhound USAOCTA3h 53m • 2 changes
  •  → 

    San Diego Metro TransitFlixbus USAOCTA4h 53m • 2 changes
  •  → 

    San Diego Metro TransitGreyhound USAOCTA3h 58m • 2 changes
  • Show more

Departing Friday, November 13, 2026

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    San Diego Metro TransitFlixbus USAOCTA4h 14m • 2 changes
  •  → 

    San Diego Metro TransitGreyhound USAOCTA3h 53m • 2 changes
  •  → 

    San Diego Metro TransitFlixbus USAOCTA4h 53m • 2 changes
  •  → 

    San Diego Metro TransitGreyhound USAOCTA3h 58m • 2 changes
  • Show more

Departing Monday, November 16, 2026

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    San Diego Metro TransitFlixbus USAOCTA4h 14m • 2 changes
  •  → 

    San Diego Metro TransitGreyhound USAOCTA3h 53m • 2 changes
  •  → 

    San Diego Metro TransitFlixbus USAOCTA4h 53m • 2 changes

Frequently asked questions

Want to know about travelling from La Mesa to Irvine? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from La Mesa to Irvine.ExpandLaunch map view
  • Distance: 112.5 mi
  • Duration: 4h 24m

What companies run services between La Mesa, CA, USA and Irvine, CA, USA?

You can take a bus from University Av & College Av to Main-Harvard via Old Town Transit Center, San Diego, Anaheim Regional Transportation Intermodal Center, and Artic - Dock 4 in around 4h 39m.

Operators