The average bus between La Mesa and Otay Mesa takes 2h 25m and the fastest bus takes 1h 53m. There is an hourly bus service from La Mesa to Otay Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between La Mesa and Otay Mesa. The earliest departure is at 5:19 AM in the morning, and the last departure from La Mesa is at 10:20 PM which arrives into Otay Mesa at 5:29 AM. All services require a transfer at Broadway & Park Bl and take an average of 2h 25m. The schedules shown below are for the next available departures.


1h 59m • 2 changes


2h 14m • 2 changes


2h • 2 changes


2h 6m • 2 changes


2h 6m • 2 changes


1h 53m • 2 changes


2h 8m • 2 changes


2h 9m • 2 changes


2h 21m • 2 changes


2h 8m • 2 changes


2h 23m • 2 changes


2h 24m • 2 changes
Want to know about travelling from La Mesa to Otay Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from La Mesa to Otay Mesa. However, there are services departing from La Mesa station and arriving at Otay Mesa station via Park Bl & Broadway. The journey, including transfers, takes approximately 2h 25m.
La Mesa to Otay Mesa bus services, operated by San Diego Metro Transit, depart from SDSU Transit Center station.
La Mesa to Otay Mesa bus services, operated by San Diego Metro Transit, arrive at Otay Mesa Transit Center station.
The distance between La Mesa and Otay Mesa is 23 km. The road distance is 60 km.
You can take a bus from SDSU Transit Center to Otay Mesa Rd & Cactus Rd via Broadway & Park Bl and Otay Mesa Transit Center in around 2h 27m.