The bus between La Mesa and San Luis Obispo takes 25h 42m. The bus runs, on average, 2 times per week from La Mesa to San Luis Obispo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice a week between La Mesa and San Luis Obispo. The earliest departure is at 11:18 AM in the morning, and the last departure from La Mesa is at 11:18 AM which arrives into San Luis Obispo at 1:00 PM. All services require a transfer at Old Town Transit Center and take an average of 25h 42m. The schedules shown below are for the next available departures.
Want to know about travelling from La Mesa to San Luis Obispo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from La Mesa to San Luis Obispo. However, there are services departing from La Mesa station and arriving at San Luis Obispo station via Los Angeles Downtown. The journey, including transfers, takes approximately 25h 42m.
La Mesa to San Luis Obispo bus services, operated by San Diego Metro Transit, depart from San Diego station.
La Mesa to San Luis Obispo bus services, operated by San Diego Metro Transit, arrive at San Luis Obispo Railroad Museum station.
The distance between La Mesa and San Luis Obispo is 436.4 km. The road distance is 527 km.
You can take a bus from University Av & College Av to San Luis Obispo Railroad Museum via Old Town Transit Center, San Diego, Los Angeles Downtown, and Los Angeles Union Station in around 10h 12m.
