The average bus between La Mesa and Santa Ana takes 3h 27m and the fastest bus takes 2h 46m. The bus service runs several times per day from La Mesa to Santa Ana. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between La Mesa and Santa Ana. The earliest departure is at 4:36 AM at night, and the last departure from La Mesa is at 10:19 PM which arrives into Santa Ana at 7:35 AM. All services require a transfer at Old Town Transit Center and take an average of 3h 27m. The schedules shown below are for the next available departures.
Want to know about travelling from La Mesa to Santa Ana? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from La Mesa to Santa Ana. However, there are services departing from La Mesa station and arriving at Santa Ana station via Old Town Transit Center. The journey, including transfers, takes approximately 3h 27m.
La Mesa to Santa Ana bus services, operated by San Diego Metro Transit, depart from University Av & College Av station.
La Mesa to Santa Ana bus services, operated by San Diego Metro Transit, arrive at Santa Ana Bus Stop station.
The distance between La Mesa and Santa Ana is 134.1 km. The road distance is 155 km.
You can take a bus from University Av & College Av to Santa Ana Bus Stop via Old Town Transit Center and San Diego Greyhound Bus Stop in around 3h 27m.
