Rome2Rio

La Mesa to Simi Valley buses

Find Transport to Simi Valley

View schedule

Trip Overview

The average bus between La Mesa and Simi Valley takes 12h 8m and the fastest bus takes 10h 17m. The bus service runs several times per day from La Mesa to Simi Valley. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

12h 8m
Duration
177 mi
Distance
$38
Average price
Twice daily
Frequency

La Mesa to Simi Valley bus times

Buses run twice daily between La Mesa and Simi Valley. The earliest departure is at 4:36 AM at night, and the last departure from La Mesa is at 10:19 PM which arrives into Simi Valley at 4:09 PM. All services require a transfer at Old Town Transit Center and take an average of 12h 8m. The schedules shown below are for the next available departures.

Departing Thursday, November 5, 2026

  •  → 

    Arrives next day

    San Diego Metro TransitFlixbus USAFlixbus USAMetro Los AngelesSimi Valley Transit12h 30m • 4 changes

Departing Friday, November 6, 2026

  •  → 

    San Diego Metro TransitGreyhound USAGreyhound USAMetro Los AngelesSimi Valley Transit10h 17m • 4 changes
  •  → 

    Arrives next day

    San Diego Metro TransitGreyhound USAFlixbus USAMetro Los AngelesSimi Valley Transit12h 59m • 4 changes
  •  → 

    Arrives next day

    San Diego Metro TransitFlixbus USAFlixbus USAMetro Los AngelesSimi Valley Transit11h 55m • 4 changes
  •  → 

    Arrives next day

    San Diego Metro TransitGreyhound USAGreyhound USAMetro Los AngelesSimi Valley Transit17h 50m • 4 changes

Departing Monday, November 9, 2026

  •  → 

    San Diego Metro TransitGreyhound USAGreyhound USAMetro Los AngelesSimi Valley Transit10h 17m • 4 changes
  •  → 

    Arrives next day

    San Diego Metro TransitGreyhound USAFlixbus USAMetro Los AngelesSimi Valley Transit12h 29m • 4 changes
  •  → 

    Arrives next day

    San Diego Metro TransitFlixbus USAFlixbus USAMetro Los AngelesSimi Valley Transit12h 30m • 4 changes

Departing Tuesday, November 10, 2026

  •  → 

    San Diego Metro TransitGreyhound USAGreyhound USAMetro Los AngelesSimi Valley Transit10h 17m • 4 changes
  •  → 

    Arrives next day

    San Diego Metro TransitGreyhound USAGreyhound USAMetro Los AngelesSimi Valley Transit12h 29m • 4 changes
  •  → 

    Arrives next day

    San Diego Metro TransitFlixbus USAFlixbus USAMetro Los AngelesSimi Valley Transit12h 30m • 4 changes

Departing Wednesday, November 11, 2026

  •  → 

    San Diego Metro TransitGreyhound USAGreyhound USAMetro Los AngelesSimi Valley Transit10h 17m • 4 changes

Frequently asked questions

Want to know about travelling from La Mesa to Simi Valley? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from La Mesa to Simi Valley.ExpandLaunch map view
  • Distance: 177.2 mi
  • Duration: 12h 8m

What companies run services between La Mesa, CA, USA and Simi Valley, CA, USA?

You can take a bus from University Av & College Av to Cochran Street and First Street via Old Town Transit Center, San Diego Greyhound Bus Stop, Los Angeles Union Station, Los Angeles, North Hollywood Station, Chatsworth Station, and Metrolink Chatsworth in around 8h 59m.

Operators