The average bus between La Mesa and Simi Valley takes 10h 58m and the fastest bus takes 8h 6m. The bus service runs several times per day from La Mesa to Simi Valley. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between La Mesa and Simi Valley. The earliest departure is at 4:36 AM at night, and the last departure from La Mesa is at 10:19 PM which arrives into Simi Valley at 2:00 PM. All services require a transfer at Old Town Transit Center and take an average of 10h 58m. The schedules shown below are for the next available departures.





8h 54m • 5 changes





8h 6m • 5 changes





9h 41m • 5 changes
Arrives next day





17h 25m • 5 changes





8h 54m • 5 changes





8h 6m • 5 changes





9h 41m • 5 changes
Arrives next day





17h 25m • 5 changes





8h 54m • 5 changes





8h 6m • 5 changes





9h 41m • 5 changes
Arrives next day





17h 55m • 5 changes
Want to know about travelling from La Mesa to Simi Valley? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from La Mesa to Simi Valley. However, there are services departing from La Mesa station and arriving at Simi Valley station via Old Town Transit Center. The journey, including transfers, takes approximately 10h 58m.
La Mesa to Simi Valley bus services, operated by San Diego Metro Transit, depart from University Av & College Av station.
La Mesa to Simi Valley bus services, operated by San Diego Metro Transit, arrive at Cochran Street and First Street station.
The distance between La Mesa and Simi Valley is 233.3 km. The road distance is 321 km.
You can take a bus from University Av & College Av to Cochran Street and First Street via Old Town Transit Center, San Diego, LAX Terminal 3 Shared Rides Stop, LAX Tom Bradley International Terminal, Van Nuys FlyAway Terminal - 7610 Woodley Ave, Woodley / Saticoy, Chandler / Lankershim, North Hollywood Station, Chatsworth Station, and Metrolink Chatsworth in around 10h 2m.