The average bus between Lafayette and Winston-Salem takes 20h 57m and the fastest bus takes 20h 20m. The bus service runs several times per day from Lafayette to Winston-Salem. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Lafayette and Winston-Salem. The earliest departure is at 9:35 AM in the morning, and the last departure from Lafayette is at 5:25 PM which arrives into Winston-Salem at 2:45 PM. All services require a transfer at Atlanta and take an average of 20h 57m. The schedules shown below are for the next available departures.
Arrives next day

21h 25m • 1 change
Arrives next day

21h 20m • 1 change
Arrives next day

21h 25m • 1 change
Arrives next day

21h 20m • 1 change
Arrives next day

21h 25m • 1 change
Arrives next day

21h 20m • 1 change
Want to know about travelling from Lafayette to Winston-Salem? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lafayette to Winston-Salem. However, there are services departing from Lafayette station and arriving at Winston-Salem station via Atlanta. The journey, including transfers, takes approximately 20h 57m.
Lafayette to Winston-Salem bus services, operated by Greyhound USA, depart from Lafayette station.
Lafayette to Winston-Salem bus services, operated by Greyhound USA, arrive at Winston Salem(Trans Center) station.
Book your Lafayette to Winston-Salem bus tickets online with Greyhound USA.
The distance between Lafayette and Winston-Salem is 1,274.6 km. The road distance is 1,589 km.
You can take a bus from Lafayette to Winston Salem(Trans Center) via Atlanta, Doraville Station, Civic Center Station, Atlanta Downtown, and Charlotte Bus Station in around 18h 11m.