The average bus between Lago di Como and Mendrisio takes 53 min and the fastest bus takes 45 min. There is a bus service every few hours from Lago di Como to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Lago di Como and Mendrisio. The earliest departure is at 6:27 AM in the morning, and the last departure from Lago di Como is at 7:07 PM which arrives into Mendrisio at 7:52 PM. All services require a transfer, and take on average 53 min. The schedules shown below are for the next available departures.

55 min • 1 change

45 min • 1 change

55 min • 1 change

48 min • 1 change

55 min • 1 change

45 min • 1 change

55 min • 1 change

48 min • 1 change

55 min • 1 change

45 min • 1 change

55 min • 1 change

48 min • 1 change
Want to know about travelling from Lago di Como to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lago di Como to Mendrisio. However, there are services departing from Lago di Como station and arriving at Mendrisio station via Chiasso - Stazione. The journey, including transfers, takes approximately 53 min.
Lago di Como to Mendrisio bus services, operated by ASF Autolinee S.r.l., depart from Como - Cavour station.
Lago di Como to Mendrisio bus services, operated by ASF Autolinee S.r.l., arrive at Mendrisio, Autosilo station.
The distance between Lago di Como and Mendrisio is 26 km. The road distance is 17 km.
You can take a bus from Como - Cavour to Mendrisio, Autosilo via Chiasso, Stazione in around 59 min.