The average bus between Laguna Niguel and Santa Ana takes 57 min and the fastest bus takes 47 min. The bus service runs several times per day from Laguna Niguel to Santa Ana. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 3 hours between Laguna Niguel and Santa Ana. The earliest departure is at 5:06 AM in the morning, and the last departure from Laguna Niguel is at 6:05 PM which arrives into Santa Ana at 7:07 PM. All services require a transfer at Paseo De Valencia-Calle De Los Caballeros and take an average of 57 min. The schedules shown below are for the next available departures.

47 min • 1 change

51 min • 1 change

58 min • 1 change

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47 min • 1 change

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58 min • 1 change

50 min • 1 change

47 min • 1 change

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58 min • 1 change

50 min • 1 change

47 min • 1 change

51 min • 1 change

58 min • 1 change

50 min • 1 change
Want to know about travelling from Laguna Niguel to Santa Ana? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Laguna Niguel to Santa Ana. However, there are services departing from Laguna Niguel station and arriving at Santa Ana station via Paseo De Valencia-Calle De Los Caballeros. The journey, including transfers, takes approximately 57 min.
Laguna Niguel to Santa Ana bus services, operated by OCTA, depart from Niguel-Crown Valley station.
Laguna Niguel to Santa Ana bus services, operated by OCTA, arrive at Civic Center-Main station.
The distance between Laguna Niguel and Santa Ana is 28.9 km. The road distance is 35 km.
You can take a bus from Niguel-Crown Valley to Civic Center-Main via Paseo De Valencia-Calle De Los Caballeros and Laguna Hills Trans Ctr Dock 5 in around 1h 6m.