Rome2Rio

Lake City to Biloxi buses

Find Transport to Biloxi

View schedule

Trip Overview

The average bus between Lake City and Biloxi takes 11h 48m and the fastest bus takes 11h 10m. The bus service runs several times per day from Lake City to Biloxi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

11h 48m
Duration
420 mi
Distance
$90
Average price
Twice daily
Frequency

Lake City to Biloxi bus times

Buses run twice daily between Lake City and Biloxi. The earliest departure is at 9:35 AM in the morning, and the last departure from Lake City is at 5:25 PM which arrives into Biloxi at 3:35 AM. All services require a transfer at Tallahassee and take an average of 11h 48m. The schedules shown below are for the next available departures.

Departing Saturday, November 7, 2026

  •  → 

    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA11h 10m • 2 changes

Departing Sunday, November 8, 2026

  •  → 

    Greyhound USAGreyhound USAFlixbus USA12h 35m • 2 changes
  •  → 

    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA11h 10m • 2 changes

Departing Monday, November 9, 2026

  •  → 

    Greyhound USAGreyhound USAFlixbus USA12h 35m • 2 changes
  •  → 

    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA11h 10m • 2 changes

Departing Tuesday, November 10, 2026

  •  → 

    Greyhound USAGreyhound USAFlixbus USA12h 35m • 2 changes
  •  → 

    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA11h 10m • 2 changes

Departing Wednesday, November 11, 2026

  •  → 

    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA11h 10m • 2 changes

Departing Thursday, November 12, 2026

  •  → 

    Greyhound USAGreyhound USAFlixbus USA12h 35m • 2 changes
  •  → 

    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA11h 10m • 2 changes

Frequently asked questions

Want to know about travelling from Lake City to Biloxi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Lake City to Biloxi.ExpandLaunch map view
  • Distance: 420.5 mi
  • Duration: 11h 48m

What companies run services between Lake City, FL, USA and Biloxi, MS, USA?

You can take a bus from Lake City Bus Station to Biloxi Transit Center via Tallahassee and Mobile Bus Station in around 10h 45m.

Operators