Rome2Rio

Lake City to Gainesville buses

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Trip Overview

The bus between Lake City and Gainesville takes 16h 29m. The bus runs, on average, 6 times per week from Lake City to Gainesville. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

16h 29m
Duration
128 mi
Distance
$26
Average price
6 times a week
Frequency

Lake City to Gainesville bus times

Buses run 6 times a week between Lake City and Gainesville. The service departs Lake City at 7:30 PM in the evening, which arrives into Gainesville at 11:59:00. All services require a transfer, and take on average 16h 29m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

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    Arrives next day

    Greyhound USAFlixbus USA16h 29m • 1 change

Departing Friday, November 13, 2026

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    Arrives next day

    Greyhound USAFlixbus USA16h 29m • 1 change

Departing Saturday, November 14, 2026

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    Arrives next day

    Greyhound USAFlixbus USA16h 29m • 1 change

Departing Sunday, November 15, 2026

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    Arrives next day

    Greyhound USAFlixbus USA16h 29m • 1 change

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USA16h 29m • 1 change

Frequently asked questions

Want to know about travelling from Lake City to Gainesville? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Lake City to Gainesville.ExpandLaunch map view
  • Distance: 128.4 mi
  • Duration: 16h 29m

What companies run services between Lake City, FL, USA and Gainesville, FL, USA?

You can take a bus from Lake City Bus Station to Gainesville via Jacksonville in around 3h 34m.

Operators