Rome2Rio

Lake City to Indianapolis buses

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Trip Overview

The bus between Lake City and Indianapolis takes 22h 20m. The bus runs, on average, 6 times per week from Lake City to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

22h 20m
Duration
860 mi
Distance
$173
Average price
6 times a week
Frequency

Lake City to Indianapolis bus times

Buses run 6 times a week between Lake City and Indianapolis. The service departs Lake City at 9:35 AM in the morning, which arrives into Indianapolis at 07:55:00. All services require a transfer, and take on average 22h 20m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

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    Arrives next day

    Greyhound USAFlixbus USA22h 20m • 1 change

Departing Friday, November 13, 2026

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    Arrives next day

    Greyhound USAFlixbus USA22h 20m • 1 change

Departing Saturday, November 14, 2026

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    Arrives next day

    Greyhound USAFlixbus USA22h 20m • 1 change

Departing Sunday, November 15, 2026

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    Arrives next day

    Greyhound USAFlixbus USA22h 20m • 1 change

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USA22h 20m • 1 change

Frequently asked questions

Want to know about travelling from Lake City to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Lake City to Indianapolis.ExpandLaunch map view
  • Distance: 859.6 mi
  • Duration: 22h 20m

What companies run services between Lake City, FL, USA and Indianapolis, IN, USA?

You can take a bus from Lake City Bus Station to Indianapolis via Atlanta Bus Station in around 18h 30m.

Operators