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Lake City to Niagara Falls buses

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Trip Overview

The average bus between Lake City and Niagara Falls takes 47h 3m and the fastest bus takes 46h 10m. The bus runs, on average, 4 times per week from Lake City to Niagara Falls. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

47h 3m
Duration
1,423 mi
Distance
$273
Average price
4 times a week
Frequency

Lake City to Niagara Falls bus times

Buses run 4 times a week between Lake City and Niagara Falls. The service departs Lake City at 7:30 PM in the evening, which arrives into Niagara Falls at 21:15:00. All services require a transfer at Jacksonville and take an average of 47h 3m. The schedules shown below are for the next available departures.

Departing Sunday, November 8, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USA2d 1h • 2 changes

Departing Wednesday, November 11, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USA46h 10m • 2 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USA46h 10m • 2 changes

Frequently asked questions

Want to know about travelling from Lake City to Niagara Falls? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Lake City to Niagara Falls.ExpandLaunch map view
  • Distance: 1,423.3 mi
  • Duration: 47h 3m

What companies run services between Lake City, FL, USA and Niagara Falls, NY, USA?

You can take a bus from Lake City Bus Station to Niagara Falls USA via Jacksonville and Newark Penn Station in around 29h 20m.

Operators