The average bus between Lake Erie and Syracuse takes 3h 47m and the fastest bus takes 3h 18m. There is a bus service every few hours from Lake Erie to Syracuse. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Lake Erie and Syracuse. The earliest departure is at 5:06 AM in the morning, and the last departure from Lake Erie is at 11:59 PM which arrives into Syracuse at 3:20 AM. All services require a transfer at South Division Street & Ellicott Loop and take an average of 3h 47m. The schedules shown below are for the next available departures.

3h 18m • 1 change

3h 38m • 1 change

3h 23m • 1 change

3h 27m • 1 change

3h 18m • 1 change

3h 43m • 1 change

3h 23m • 1 change

3h 27m • 1 change

3h 18m • 1 change

3h 43m • 1 change

3h 23m • 1 change

3h 27m • 1 change

3h 18m • 1 change

3h 38m • 1 change

3h 23m • 1 change

3h 27m • 1 change
Want to know about travelling from Lake Erie to Syracuse? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lake Erie to Syracuse. However, there are services departing from Lake Erie station and arriving at Syracuse station via Syracuse. The journey, including transfers, takes approximately 3h 47m.
Lake Erie to Syracuse bus services, operated by NFTA, depart from Buffalo station.
Lake Erie to Syracuse bus services, operated by NFTA, arrive at Syracuse station.
The distance between Lake Erie and Syracuse is 439.1 km. The road distance is 266 km.
Trailways operates a bus from Buffalo to Syracuse every 4 hours. Tickets cost $28–100 and the journey takes 3h 20m. Two other operators also service this route.