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Lake Okeechobee to Florida Keys buses

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Trip Overview

The bus between Lake Okeechobee and Florida Keys takes 20h 58m. The bus runs, on average, 6 times per week from Lake Okeechobee to Florida Keys. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

20h 58m
Duration
243 mi
Distance
$90
Average price
6 times a week
Frequency

Lake Okeechobee to Florida Keys bus times

Buses run 6 times a week between Lake Okeechobee and Florida Keys. The service departs Lake Okeechobee at 3:17 PM in the afternoon, which arrives into Florida Keys at 12:15:00. All services require a transfer at Nw 22 Av & Nw 11 St and take an average of 20h 58m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

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    Arrives next day

    Hendry County Transit SystemGreyhound USAGreyhound USAKey West Transit20h 58m • 3 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Hendry County Transit SystemGreyhound USAGreyhound USAKey West Transit20h 58m • 3 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    Hendry County Transit SystemGreyhound USAGreyhound USAKey West Transit20h 58m • 3 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Hendry County Transit SystemGreyhound USAGreyhound USAKey West Transit20h 58m • 3 changes

Departing Monday, November 16, 2026

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    Arrives next day

    Hendry County Transit SystemGreyhound USAGreyhound USAKey West Transit20h 58m • 3 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives next day

    Hendry County Transit SystemGreyhound USAGreyhound USAKey West Transit20h 58m • 3 changes

Frequently asked questions

Want to know about travelling from Lake Okeechobee to Florida Keys? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Lake Okeechobee to Florida Keys.ExpandLaunch map view
  • Distance: 243.2 mi
  • Duration: 20h 58m

What companies run services between Lake Okeechobee, Palm Beach County, FL, USA and Florida Keys, FL, USA?

You can take a bus from Clewiston to Florida Keys via Nw 22 Av & Nw 11 St, Earlington Heights Metrorail Station, Earlington Hts.Stat.Rail Northbound, Miami, Airport Intermodal Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 9h 7m.

Operators