The average bus between Lastra a Signa and Rome takes 5h 30m and the fastest bus takes 3h 34m. The bus service runs several times per day from Lastra a Signa to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Lastra a Signa and Rome. The earliest departure is at 6:24 AM in the morning, and the last departure from Lastra a Signa is at 8:55 PM which arrives into Rome at 5:40 AM. All services require a transfer at T1 De André and take an average of 5h 30m. The schedules shown below are for the next available departures.

3h 35m • 1 change
3h 36m • 1 changeArrives next day

10h 46m • 1 change
3h 35m • 1 change
3h 36m • 1 changeArrives next day

10h 46m • 1 change
3h 35m • 1 change
3h 36m • 1 changeArrives next day

10h 46m • 1 change
3h 35m • 1 change
3h 53m • 1 change
3h 34m • 1 changeArrives next day

10h 44m • 1 changeWant to know about travelling from Lastra a Signa to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lastra a Signa to Rome. However, there are services departing from Lastra a Signa station and arriving at Rome station via Rome Tiburtina Bus station station. The journey, including transfers, takes approximately 5h 30m.
Lastra a Signa to Rome bus services, operated by Autolinee Toscane, depart from Florence station.
Lastra a Signa to Rome bus services, operated by Autolinee Toscane, arrive at Rome Tiburtina Bus station.
The distance between Lastra a Signa and Rome is 236.6 km. The road distance is 282 km.
FlixBus operates a bus from Florence to Rome Tiburtina Bus station 5 times a day. Tickets cost €22–40 and the journey takes 3h 15m. Two other operators also service this route.