Rome2Rio

Lewes to Buffalo buses

Find Transport to Buffalo

View schedule
QR code to download the Rome2Rio app

Download the Rome2Rio travel app

Scan QR code with your phone to download the app

Download on the App StoreGet it on Google Play

Trip Overview

The average bus between Lewes and Buffalo takes 23h 21m and the fastest bus takes 21h 13m. The bus runs, on average, 2 times per week from Lewes to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

23h 21m
Duration
602 mi
Distance
$116
Average price
Twice a week
Frequency

Lewes to Buffalo bus times

Buses run twice a week between Lewes and Buffalo. The earliest departure is at 3:30 PM in the afternoon, and the last departure from Lewes is at 7:47 PM which arrives into Buffalo at 5:00 PM. All services require a transfer at Lewes Transit Center and take an average of 23h 21m. The schedules shown below are for the next available departures.

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    DART First StateDART First StateGreyhound USAFlixbus USA21h 13m • 3 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    DART First StateDART First StateGreyhound USAFlixbus USA25h 30m • 3 changes

Frequently asked questions

Want to know about travelling from Lewes to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Lewes to Buffalo.ExpandLaunch map view
  • Distance: 601.8 mi
  • Duration: 23h 21m

What companies run services between Lewes, DE, USA and Buffalo, NY, USA?

You can take a bus from Market St @ 2Nd St to Buffalo via Lewes Transit Center, Wilmington Tc, Wilmington Bus Station, and Newark Penn Station in around 15h 33m.

Operators