The average bus between Lisbon Region and Prague takes 42h 42m and the fastest bus takes 40h 23m. The bus service runs several times per day from Lisbon Region to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Lisbon Region and Prague. The earliest departure is at 7:42 AM in the morning, and the last departure from Lisbon Region is at 4:21 PM which arrives into Prague at 9:45 AM. All services require a transfer at Estação Oriente and take an average of 42h 42m. The schedules shown below are for the next available departures.
Arrives +2 days


42h 53m • 2 changes
Arrives +2 days


41h 32m • 2 changes
Arrives +2 days


45h 27m • 2 changes
Arrives +2 days


41h 32m • 2 changes
Arrives +2 days


42h 53m • 2 changes
Arrives +2 days


41h 32m • 2 changes
Want to know about travelling from Lisbon Region to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lisbon Region to Prague. However, there are services departing from Lisbon Region station and arriving at Prague station via Paris. The journey, including transfers, takes approximately 42h 42m.
Lisbon Region to Prague bus services, operated by Carris, depart from Lisbon station.
Lisbon Region to Prague bus services, operated by Carris, arrive at Prague - Florenc Main Bus Terminal station.
The distance between Lisbon Region and Prague is 2,243.9 km. The road distance is 2,772 km.
You can take a bus from Sul e Sueste to Prague - Florenc Main Bus Terminal via Estação Oriente, Lisbon, Paris, and Paris - Bercy-Seine Bus Station in around 37h 35m.