The average bus between London Paddington and Manchester takes 4h 43m and the fastest bus takes 4h 12m. There is a bus service every few hours from London Paddington to Manchester. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between London Paddington and Manchester. The earliest departure is at 7:02 AM in the morning, and the last departure from London Paddington is at 9:10 PM which arrives into Manchester at 2:00 AM. All services require a transfer at Warwick Avenue and take an average of 4h 43m. The schedules shown below are for the next available departures.

4h 38m • 1 change
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4h 32m • 1 changeWant to know about travelling from London Paddington to Manchester? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from London Paddington to Manchester. However, there are services departing from London Paddington station and arriving at Manchester station via Manchester, Shudehill Interchange. The journey, including transfers, takes approximately 4h 43m.
London Paddington to Manchester bus services, operated by Metroline Travel, depart from London, Finchley Road ("Subway" restaurant) station.
London Paddington to Manchester bus services, operated by Metroline Travel, arrive at Manchester, Shudehill Interchange station.
Book your London Paddington to Manchester bus tickets online with Metroline Travel and FlixBus.
The distance between London Paddington and Manchester is 259.1 km. The road distance is 314 km.
FlixBus operates a bus from London, Finchley Road ("Subway" restaurant) to Manchester, Shudehill Interchange hourly. Tickets cost £22–35 and the journey takes 4h 10m.