The average bus between Los Angeles Union Station and Otay Mesa takes 6h 13m and the fastest bus takes 4h 29m. The bus service runs several times per day from Los Angeles Union Station to Otay Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Los Angeles Union Station and Otay Mesa. The earliest departure is at 6:05 AM in the morning, and the last departure from Los Angeles Union Station is at 8:20 PM which arrives into Otay Mesa at 5:55 AM. All services require a transfer at San Ysidro and take an average of 6h 13m. The schedules shown below are for the next available departures.


5h 4m • 2 changes


4h 49m • 2 changes
Arrives next day


8h 43m • 2 changes


5h 14m • 2 changes


4h 29m • 2 changes
Arrives next day


8h 43m • 2 changes


5h 14m • 2 changes


4h 29m • 2 changes
Arrives next day


8h 43m • 2 changes


5h 14m • 2 changes


4h 29m • 2 changes
Arrives next day


8h 43m • 2 changes


5h 14m • 2 changes


4h 29m • 2 changes
Arrives next day


8h 43m • 2 changes
Want to know about travelling from Los Angeles Union Station to Otay Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Los Angeles Union Station to Otay Mesa. However, there are services departing from Los Angeles Union Station station and arriving at Otay Mesa station via San Ysidro. The journey, including transfers, takes approximately 6h 13m.
Los Angeles Union Station to Otay Mesa bus services, operated by Greyhound Mexico, depart from Los Angeles Union Station.
Los Angeles Union Station to Otay Mesa bus services, operated by Greyhound Mexico, arrive at San Ysidro station.
The distance between Los Angeles Union Station and Otay Mesa is 202.3 km. The road distance is 235 km.
Greyhound Mexico operates a bus from Los Angeles Union Station to San Ysidro 3 times a day. Tickets cost $26–45 and the journey takes 3h 30m.