The average bus between Los Angeles and Mesa takes 9h 56m and the fastest bus takes 8h 50m. The bus service runs several times per day from Los Angeles to Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Los Angeles and Mesa. The earliest departure is at 8:35 AM in the morning, and the last departure from Los Angeles is at 11:30 PM which arrives into Mesa at 8:45 AM. All services require a transfer at Indio and take an average of 9h 56m. The schedules shown below are for the next available departures.


9h 56m • 2 changes
Arrives next day


15h 52m • 2 changes
Arrives next day


10h 20m • 2 changes
Arrives next day


8h 50m • 2 changes
Want to know about travelling from Los Angeles to Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Los Angeles to Mesa. However, there are services departing from Los Angeles station and arriving at Mesa station via Indio. The journey, including transfers, takes approximately 9h 56m.
Los Angeles to Mesa bus services, operated by Greyhound USA, depart from Los Angeles Downtown station.
Los Angeles to Mesa bus services, operated by Greyhound USA, arrive at Phoenix station.
Book your Los Angeles to Mesa bus tickets online with Greyhound USA, Valley Metro and Flixbus USA.
The distance between Los Angeles and Mesa is 597.8 km. The road distance is 627 km.
You can take a bus from Los Angeles Downtown to Mesa Dr/Main St via Indio, Indio, CA, Phoenix, and 24th St/Jefferson in around 7h 58m.