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Los Angeles to Santa Fe Depot buses

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Trip Overview

The bus between Los Angeles and Santa Fe Depot takes 3h. There is at least one bus per day from Los Angeles to Santa Fe Depot. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3h
Duration
122 mi
Distance
$26
Average price
Once daily
Frequency

Los Angeles to Santa Fe Depot bus times

Buses run once daily between Los Angeles and Santa Fe Depot. The service departs Los Angeles at 2:35 AM at night, which arrives into Santa Fe Depot at 05:35:00. All services run direct with no transfers required, and take on average 3h. The schedules shown below are for the next available departures.

Departing Sunday, November 8, 2026

  •  → 

    bus bus 3h • Direct

Departing Monday, November 9, 2026

  •  → 

    bus bus 3h • Direct

Departing Tuesday, November 10, 2026

  •  → 

    bus bus 3h • Direct

Departing Wednesday, November 11, 2026

  •  → 

    bus bus 3h • Direct

Departing Thursday, November 12, 2026

  •  → 

    bus bus 3h • Direct

Departing Friday, November 13, 2026

  •  → 

    bus bus 3h • Direct

Frequently asked questions

Want to know about travelling from Los Angeles to Santa Fe Depot? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Los Angeles to Santa Fe Depot.ExpandLaunch map view
  • Distance: 122.1 mi
  • Duration: 3h

What companies run services between Los Angeles, CA, USA and Santa Fe Depot, San Diego County, CA, USA?

Greyhound USA operates a bus from Los Angeles Union Station to San Diego Greyhound Bus Stop every 4 hours. Tickets cost $21–35 and the journey takes 2h 35m. Flixbus USA also services this route twice daily.

Operators