The average bus between Los Osos and Santa Maria takes 2h 37m and the fastest bus takes 1h 53m. The bus service runs several times per day from Los Osos to Santa Maria. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 3 hours between Los Osos and Santa Maria. The earliest departure is at 6:23 AM in the morning, and the last departure from Los Osos is at 9:20 PM which arrives into Santa Maria at 7:08 AM. All services require a transfer, and take on average 2h 37m. The schedules shown below are for the next available departures.

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Want to know about travelling from Los Osos to Santa Maria? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Los Osos to Santa Maria. However, there are services departing from Los Osos station and arriving at Santa Maria station via Government Center. The journey, including transfers, takes approximately 2h 37m.
Los Osos to Santa Maria bus services, operated by San Luis Obispo RTA, depart from Ramona & 7th station.
Los Osos to Santa Maria bus services, operated by San Luis Obispo RTA, arrive at Santa Maria Transit Center station.
The distance between Los Osos and Santa Maria is 53.7 km. The road distance is 89 km.
You can take a bus from Ramona & 7th to Santa Maria Transit Center via Government Center in around 2h 50m.