The average bus between Louisville and Biloxi takes 22h 8m and the fastest bus takes 21h 45m. The bus service runs several times per day from Louisville to Biloxi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Louisville and Biloxi. The earliest departure is at 6:00 AM in the morning, and the last departure from Louisville is at 6:20 PM which arrives into Biloxi at 3:05 PM. All services require a transfer at Nashville Bus Station and take an average of 22h 8m. The schedules shown below are for the next available departures.
Arrives next day


21h 35m • 2 changes
Arrives next day


20h 45m • 2 changes
Arrives next day


21h 35m • 2 changes
Arrives next day


20h 45m • 2 changes
Arrives next day


21h 35m • 2 changes
Arrives next day


20h 45m • 2 changes
Arrives next day


21h 35m • 2 changes
Arrives next day


20h 45m • 2 changes
Want to know about travelling from Louisville to Biloxi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Louisville to Biloxi. However, there are services departing from Louisville station and arriving at Biloxi station via Nashville. The journey, including transfers, takes approximately 22h 8m.
Louisville to Biloxi bus services, operated by Amtrak Thruway, depart from Louisville, KY station.
Louisville to Biloxi bus services, operated by Amtrak Thruway, arrive at Biloxi Transit Center station.
Book your Louisville to Biloxi bus tickets online with Amtrak Thruway and Greyhound USA.
The distance between Louisville and Biloxi is 919.6 km. The road distance is 1,096 km.
You can take a bus from Louisville, KY to Biloxi Transit Center via Nashville Bus Station and Montgomery Intermodal Center in around 14h 55m.