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Louisville to Biloxi buses

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Trip Overview

The average bus between Louisville and Biloxi takes 21h 23m and the fastest bus takes 21h 10m. The bus service runs several times per day from Louisville to Biloxi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

21h 23m
Duration
681 mi
Distance
$147
Average price
Twice daily
Frequency

Louisville to Biloxi bus times

Buses run twice daily between Louisville and Biloxi. The earliest departure is at 7:25 AM in the morning, and the last departure from Louisville is at 6:30 PM which arrives into Biloxi at 3:05 PM. All services require a transfer at Nashville Bus Station and take an average of 21h 23m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Arrives next day

    Amtrak ThruwayGreyhound USAGreyhound USA21h 10m • 2 changes
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    Arrives next day

    Amtrak ThruwayGreyhound USAGreyhound USA21h 35m • 2 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    Amtrak ThruwayGreyhound USAGreyhound USA21h 10m • 2 changes
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    Arrives next day

    Amtrak ThruwayGreyhound USAGreyhound USA21h 35m • 2 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Amtrak ThruwayGreyhound USAGreyhound USA21h 10m • 2 changes
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    Arrives next day

    Amtrak ThruwayGreyhound USAGreyhound USA21h 35m • 2 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    Amtrak ThruwayGreyhound USAGreyhound USA21h 10m • 2 changes
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    Arrives next day

    Amtrak ThruwayGreyhound USAGreyhound USA21h 35m • 2 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Amtrak ThruwayGreyhound USAGreyhound USA21h 10m • 2 changes
  •  → 

    Arrives next day

    Amtrak ThruwayGreyhound USAGreyhound USA21h 35m • 2 changes

Departing Monday, November 16, 2026

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    Arrives next day

    Amtrak ThruwayGreyhound USAGreyhound USA21h 10m • 2 changes
  •  → 

    Arrives next day

    Amtrak ThruwayGreyhound USAGreyhound USA21h 35m • 2 changes

Frequently asked questions

Want to know about travelling from Louisville to Biloxi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Louisville to Biloxi.ExpandLaunch map view
  • Distance: 681.2 mi
  • Duration: 21h 23m

What companies run services between Louisville, KY, USA and Biloxi, MS, USA?

You can take a bus from Louisville, KY to Biloxi Transit Center via Nashville Bus Station and Montgomery Intermodal Center in around 14h 35m.

Operators