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Louisville to Chicago Union Station buses

Find Transport to Chicago Union Station

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Trip Overview

The average bus between Louisville and Chicago Union Station takes 6h 37m and the fastest bus takes 6h. The bus service runs several times per day from Louisville to Chicago Union Station. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

6h 37m
Duration
299 mi
Distance
$55
Average price
Twice daily
Frequency

Louisville to Chicago Union Station bus times

Buses run twice daily between Louisville and Chicago Union Station. The earliest departure is at 2:55 AM at night, and the last departure from Louisville is at 8:00 AM which arrives into Chicago Union Station at 2:15 PM. All services run direct with no transfers required, and take on average 6h 37m. The schedules shown below are for the next available departures.

Departing Monday, November 2, 2026

  •  → 

    bus bus 6h • Direct
  •  → 

    bus bus 7h 15m • Direct

Departing Tuesday, November 3, 2026

  •  → 

    bus bus 6h • Direct
  •  → 

    bus bus 7h 15m • Direct

Departing Wednesday, November 4, 2026

  •  → 

    bus bus 6h • Direct
  •  → 

    bus bus 7h 15m • Direct

Departing Thursday, November 5, 2026

  •  → 

    bus bus 6h • Direct
  •  → 

    bus bus 7h 15m • Direct

Departing Friday, November 6, 2026

  •  → 

    bus bus 6h • Direct
  •  → 

    bus bus 7h 15m • Direct

Departing Saturday, November 7, 2026

  •  → 

    bus bus 6h • Direct
  •  → 

    bus bus 7h 15m • Direct

Departing Sunday, November 8, 2026

  •  → 

    bus bus 6h • Direct

Frequently asked questions

Want to know about travelling from Louisville to Chicago Union Station? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Louisville to Chicago Union Station.ExpandLaunch map view
  • Distance: 299.1 mi
  • Duration: 6h 37m

What companies run services between Louisville, KY, USA and Chicago Union Station, IL, USA?

Amtrak Thruway operates a bus from Louisville, KY to Chicago Union Station twice daily. Tickets cost $50–60 and the journey takes 6h.

Operators