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Louisville to Jacksonville buses

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Trip Overview

The average bus between Louisville and Jacksonville takes 17h 56m and the fastest bus takes 15h 40m. The bus service runs several times per day from Louisville to Jacksonville. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

17h 56m
Duration
805 mi
Distance
$177
Average price
Twice daily
Frequency

Louisville to Jacksonville bus times

Buses run twice daily between Louisville and Jacksonville. The earliest departure is at 7:25 AM in the morning, and the last departure from Louisville is at 6:30 PM which arrives into Jacksonville at 1:35 PM. All services require a transfer at Nashville Bus Station and take an average of 17h 56m. The schedules shown below are for the next available departures.

Departing Monday, November 2, 2026

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    Amtrak ThruwayGreyhound USAFlixbus USA15h 40m • 2 changes
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    Arrives next day

    Amtrak ThruwayFlixbus USAFlixbus USA19h 5m • 2 changes

Departing Tuesday, November 3, 2026

  •  → 

    Amtrak ThruwayGreyhound USAFlixbus USA15h 40m • 2 changes
  •  → 

    Arrives next day

    Amtrak ThruwayFlixbus USAFlixbus USA19h 5m • 2 changes

Departing Wednesday, November 4, 2026

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    Arrives next day

    Amtrak ThruwayGreyhound USAFlixbus USA23h 35m • 2 changes
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    Arrives next day

    Amtrak ThruwayFlixbus USAFlixbus USA19h 5m • 2 changes

Departing Thursday, November 5, 2026

  •  → 

    Amtrak ThruwayGreyhound USAFlixbus USA15h 40m • 2 changes
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    Arrives next day

    Amtrak ThruwayFlixbus USAFlixbus USA19h 5m • 2 changes

Departing Friday, November 6, 2026

  •  → 

    Amtrak ThruwayGreyhound USAFlixbus USA15h 40m • 2 changes
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    Arrives next day

    Amtrak ThruwayFlixbus USAFlixbus USA19h 5m • 2 changes

Departing Saturday, November 7, 2026

  •  → 

    Amtrak ThruwayGreyhound USAFlixbus USA15h 40m • 2 changes
  •  → 

    Arrives next day

    Amtrak ThruwayFlixbus USAFlixbus USA19h 5m • 2 changes

Departing Sunday, November 8, 2026

  •  → 

    Amtrak ThruwayGreyhound USAFlixbus USA15h 40m • 2 changes

Frequently asked questions

Want to know about travelling from Louisville to Jacksonville? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Louisville to Jacksonville.ExpandLaunch map view
  • Distance: 805.4 mi
  • Duration: 17h 56m

What companies run services between Louisville, KY, USA and Jacksonville, FL, USA?

You can take a bus from Louisville, KY to Jacksonville via Nashville Bus Station and Atlanta Bus Station in around 16h.

Operators