Rome2Rio

Louisville to Massachusetts buses

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Trip Overview

The average bus between Louisville and Massachusetts takes 35h 46m and the fastest bus takes 32h 20m. There is at least one bus per day from Louisville to Massachusetts. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

35h 46m
Duration
1,257 mi
Distance
$237
Average price
Once daily
Frequency

Louisville to Massachusetts bus times

Buses run once daily between Louisville and Massachusetts. The earliest departure is at 2:55 AM at night, and the last departure from Louisville is at 8:00 AM which arrives into Massachusetts at 10:05 PM. All services require a transfer at Lafayette Amtrak Station and take an average of 35h 46m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

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    Arrives next day

    Amtrak ThruwayFlixbus USAFlixbus USA38h 5m • 2 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Amtrak ThruwayFlixbus USAFlixbus USA32h 20m • 2 changes
  •  → 

    Arrives next day

    Amtrak ThruwayFlixbus USAFlixbus USA38h 5m • 2 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    Amtrak ThruwayFlixbus USAFlixbus USA32h 20m • 2 changes
  •  → 

    Arrives next day

    Amtrak ThruwayFlixbus USAFlixbus USA38h 5m • 2 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    Amtrak ThruwayFlixbus USAFlixbus USA32h 20m • 2 changes
  •  → 

    Arrives next day

    Amtrak ThruwayFlixbus USAFlixbus USA38h 5m • 2 changes

Departing Monday, November 16, 2026

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    Arrives next day

    Amtrak ThruwayFlixbus USAFlixbus USA34h 30m • 2 changes

Frequently asked questions

Want to know about travelling from Louisville to Massachusetts? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Louisville to Massachusetts.ExpandLaunch map view
  • Distance: 1,257.2 mi
  • Duration: 35h 46m

What companies run services between Louisville, KY, USA and Massachusetts, USA?

You can take a bus from Louisville, KY to Boston via Lafayette Amtrak Station, Lafayette Bus Stop, and New York Midtown in around 27h 24m.

Operators