The average bus between Louisville and Opelika takes 13h 59m and the fastest bus takes 11h 30m. The bus service runs several times per day from Louisville to Opelika. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Louisville and Opelika. The earliest departure is at 3:35 AM at night, and the last departure from Louisville is at 10:15 PM which arrives into Opelika at 8:45 AM. All services require a transfer at Nashville Bus Station and take an average of 13h 59m. The schedules shown below are for the next available departures.

14h 35m • 1 change
15h 20m • 1 changeArrives next day

11h 30m • 1 change
14h 35m • 1 change
15h 20m • 1 changeArrives next day

15h 15m • 1 change
14h 35m • 1 change
15h 20m • 1 changeArrives next day

11h 30m • 1 change
14h 35m • 1 change
15h 20m • 1 changeArrives next day

11h 30m • 1 changeWant to know about travelling from Louisville to Opelika? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Louisville to Opelika. However, there are services departing from Louisville station and arriving at Opelika station via Nashville Bus Station station. The journey, including transfers, takes approximately 13h 59m.
Louisville to Opelika bus services, operated by Greyhound USA, depart from Louisville Bus Station.
Louisville to Opelika bus services, operated by Greyhound USA, arrive at Opelika 4th Street Station.
Book your Louisville to Opelika bus tickets online with Greyhound USA and Flixbus USA.
The distance between Louisville and Opelika is 624.6 km. The road distance is 887 km.
You can take a bus from Louisville Bus Station to Opelika 4th Street Station via Nashville Bus Station, Atlanta Bus Station, Garnett Station, Doraville Station, and Atlanta in around 11h 51m.