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Louisville to Roanoke buses

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Trip Overview

The bus between Louisville and Roanoke takes 20h 15m. The bus runs, on average, 6 times per week from Louisville to Roanoke. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

20h 15m
Duration
609 mi
Distance
$132
Average price
6 times a week
Frequency

Louisville to Roanoke bus times

Buses run 6 times a week between Louisville and Roanoke. The service departs Louisville at 7:25 AM in the morning, which arrives into Roanoke at 03:40:00. All services require a transfer, and take on average 20h 15m. The schedules shown below are for the next available departures.

Departing Tuesday, November 3, 2026

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    Arrives next day

    Amtrak ThruwayGreyhound USA20h 15m • 1 change

Departing Wednesday, November 4, 2026

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    Arrives next day

    Amtrak ThruwayGreyhound USA20h 15m • 1 change

Departing Thursday, November 5, 2026

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    Arrives next day

    Amtrak ThruwayGreyhound USA20h 15m • 1 change

Departing Friday, November 6, 2026

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    Arrives next day

    Amtrak ThruwayGreyhound USA20h 15m • 1 change

Departing Saturday, November 7, 2026

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    Arrives next day

    Amtrak ThruwayGreyhound USA20h 15m • 1 change

Departing Sunday, November 8, 2026

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    Arrives next day

    Amtrak ThruwayGreyhound USA20h 15m • 1 change

Frequently asked questions

Want to know about travelling from Louisville to Roanoke? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Louisville to Roanoke.ExpandLaunch map view
  • Distance: 608.9 mi
  • Duration: 20h 15m

What companies run services between Louisville, KY, USA and Roanoke, VA, USA?

You can take a bus from Louisville, KY to Roanoke Bus Stop via Nashville Bus Station in around 12h 20m.

Operators