The average bus between Louisville and San Antonio takes 25h 40m and the fastest bus takes 24h. The bus service runs several times per day from Louisville to San Antonio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Louisville and San Antonio. The earliest departure is at 6:00 AM in the morning, and the last departure from Louisville is at 6:20 PM which arrives into San Antonio at 6:10 PM. All services require a transfer at Nashville Bus Station and take an average of 25h 40m. The schedules shown below are for the next available departures.
Arrives next day


23h • 2 changes
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23h 50m • 2 changes
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23h • 2 changes
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23h 50m • 2 changes
Arrives next day


30h 55m • 2 changes
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23h 50m • 2 changes
Arrives next day


30h 55m • 2 changes
Arrives next day


23h 50m • 2 changes
Want to know about travelling from Louisville to San Antonio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Louisville to San Antonio. However, there are services departing from Louisville station and arriving at San Antonio station via Nashville. The journey, including transfers, takes approximately 25h 40m.
Louisville to San Antonio bus services, operated by Amtrak Thruway, depart from Louisville, KY station.
Louisville to San Antonio bus services, operated by Amtrak Thruway, arrive at San Antonio Bus Station.
Book your Louisville to San Antonio bus tickets online with Amtrak Thruway, Flixbus USA and Greyhound USA.
The distance between Louisville and San Antonio is 1,529.4 km. The road distance is 1,845 km.
You can take a bus from Louisville, KY to San Antonio Bus Station via Nashville Bus Station and Dallas Bus Station in around 23h 10m.