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Lowell to Buffalo buses

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Trip Overview

The average bus between Lowell and Buffalo takes 27h and the fastest bus takes 26h 45m. The bus runs, on average, 4 times per week from Lowell to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

27h
Duration
503 mi
Distance
$106
Average price
4 times a week
Frequency

Lowell to Buffalo bus times

Buses run 4 times a week between Lowell and Buffalo. The service departs Lowell at 7:50 PM in the evening, which arrives into Buffalo at 22:35:00. All services require a transfer, and take on average 27h. The schedules shown below are for the next available departures.

Departing Friday, October 30, 2026

  •  → 

    Arrives next day

    Greyhound USAGreyhound USA26h 45m • 1 change

Departing Saturday, October 31, 2026

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    Arrives next day

    Greyhound USAGreyhound USA27h 45m • 1 change

Departing Sunday, November 1, 2026

  •  → 

    Arrives next day

    Greyhound USAGreyhound USA26h 45m • 1 change

Departing Monday, November 2, 2026

  •  → 

    Arrives next day

    Greyhound USAGreyhound USA26h 45m • 1 change

Frequently asked questions

Want to know about travelling from Lowell to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Lowell to Buffalo.ExpandLaunch map view
  • Distance: 503.2 mi
  • Duration: 27h

What companies run services between Lowell, MA, USA and Buffalo, NY, USA?

You can take a bus from Robert B Kennedy Bus Transfer Center to Buffalo via Boston in around 11h 50m.

Operators