The average bus between Luton and Manchester Piccadilly Station takes 4h 34m and the fastest bus takes 3h 30m. There is a bus service every few hours from Luton to Manchester Piccadilly Station. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Luton and Manchester Piccadilly Station. The earliest departure is at 12:05 AM at night, and the last departure from Luton is at 10:45 PM which arrives into Manchester Piccadilly Station at 2:15 AM. All services require a transfer at Milton Keynes Coachway and take an average of 4h 34m. The schedules shown below are for the next available departures.

6h 10m • 1 change

4h 35m • 1 change

4h 10m • 1 change

4h 25m • 1 change

6h 10m • 1 change

4h 35m • 1 change

3h 45m • 1 change

4h 15m • 1 change

6h 10m • 1 change

4h 35m • 1 change

3h 45m • 1 change

4h 15m • 1 change

6h 10m • 1 change

4h 35m • 1 change

4h 10m • 1 change

4h 5m • 1 change
Want to know about travelling from Luton to Manchester Piccadilly Station? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Luton to Manchester Piccadilly Station. However, there are services departing from Luton station and arriving at Manchester Piccadilly Station station via Manchester Central Coach Station station. The journey, including transfers, takes approximately 4h 34m.
Luton to Manchester Piccadilly Station bus services, operated by National Express, depart from Milton Keynes Coachway station.
Luton to Manchester Piccadilly Station bus services, operated by National Express, arrive at Manchester Central Coach Station.
Book your Luton to Manchester Piccadilly Station bus tickets online with National Express.
The distance between Luton and Manchester Piccadilly Station is 215.6 km. The road distance is 278 km.
National Express operates a bus from Milton Keynes Coachway to Manchester Central Coach Station every 30 minutes. Tickets cost £29–70 and the journey takes 3h 55m.