The average bus between Lyon and Avignon Centre takes 3h 39m and the fastest bus takes 3h. The bus service runs several times per day from Lyon to Avignon Centre. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 2 hours between Lyon and Avignon Centre. The earliest departure is at 1:40 AM at night, and the last departure from Lyon is at 6:55 PM which arrives into Avignon Centre at 10:36 PM. All services require a transfer, and take on average 3h 39m. The schedules shown below are for the next available departures.

3h 56m • 1 change

3h 38m • 1 change

3h 48m • 1 change

4h 1m • 1 change

4h 25m • 1 change

5h • 1 change

3h 29m • 1 change

3h 5m • 1 change

4h 25m • 1 change

5h • 1 change

3h 29m • 1 change

3h 5m • 1 change

4h 25m • 1 change

5h • 1 change

3h 29m • 1 change

3h 5m • 1 change

4h 25m • 1 change

5h • 1 change

3h 29m • 1 change

3h 5m • 1 change
Want to know about travelling from Lyon to Avignon Centre? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lyon to Avignon Centre. However, there are services departing from Lyon station and arriving at Avignon Centre station via Avignon. The journey, including transfers, takes approximately 3h 39m.
Lyon to Avignon Centre bus services, operated by BlaBlaCar Bus, depart from Lyon station.
Lyon to Avignon Centre bus services, operated by BlaBlaCar Bus, arrive at Avignon station.
The distance between Lyon and Avignon Centre is 200.9 km. The road distance is 231 km.
FlixBus operates a bus from Lyon to Avignon every 4 hours. Tickets cost €18–35 and the journey takes 2h 40m. BlaBlaCar Bus also services this route every 4 hours.