The average bus between Lyon and Avignon Centre takes 3h 57m and the fastest bus takes 3h. The bus service runs several times per day from Lyon to Avignon Centre. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Lyon and Avignon Centre. The earliest departure is at 3:35 AM at night, and the last departure from Lyon is at 11:50 PM which arrives into Avignon Centre at 6:03 AM. All services require a transfer, and take on average 3h 57m. The schedules shown below are for the next available departures.

3h • 1 change
3h 25m • 1 change
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3h 11m • 1 change
3h 14m • 1 change
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3h 21m • 1 change
3h 53m • 1 change
3h 11m • 1 change
3h 26m • 1 change
3h 6m • 1 change
3h 7m • 1 change
3h 11m • 1 change
3h 26m • 1 change
3h 6m • 1 change
3h 7m • 1 change
3h 14m • 1 change
3h 1m • 1 change
3h 21m • 1 change
3h 53m • 1 change
3h 26m • 1 change
3h 6m • 1 change
3h 7m • 1 change
3h 47m • 1 changeWant to know about travelling from Lyon to Avignon Centre? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lyon to Avignon Centre. However, there are services departing from Lyon station and arriving at Avignon station via Avignon station. The journey, including transfers, takes approximately 3h 57m.
Lyon to Avignon Centre bus services, operated by FlixBus, depart from Lyon station.
Lyon to Avignon Centre bus services, operated by FlixBus, arrive at Avignon station.
The distance between Lyon and Avignon Centre is 200.9 km. The road distance is 225 km.
FlixBus operates a bus from Lyon to Avignon every 3 hours. Tickets cost €19–29 and the journey takes 2h 45m. BlaBlaCar Bus also services this route 4 times a day.