The average bus between Lyon and Italy takes 15h 19m and the fastest bus takes 14h 35m. The bus service runs several times per day from Lyon to Italy. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Lyon and Italy. The earliest departure is at 1:15 AM at night, and the last departure from Lyon is at 3:30 PM which arrives into Italy at 7:29 AM. All services require a transfer, and take on average 15h 19m. The schedules shown below are for the next available departures.

15h 26m • 1 change

15h 11m • 1 change
Arrives next day

14h 35m • 1 change
Arrives next day

15h 52m • 1 change

15h 26m • 1 change

15h 11m • 1 change
Arrives next day

14h 55m • 1 change
Arrives next day

15h 52m • 1 change

15h 26m • 1 change

15h 11m • 1 change
Arrives next day

14h 55m • 1 change
Arrives next day

15h 52m • 1 change

15h 26m • 1 change

15h 11m • 1 change
Arrives next day

14h 57m • 1 change
Arrives next day

16h 14m • 1 change
Want to know about travelling from Lyon to Italy? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lyon to Italy. However, there are services departing from Lyon station and arriving at Italy station via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 15h 19m.
Lyon to Italy bus services, operated by FlixBus, depart from Lyon - Gerland Bus Station.
Lyon to Italy bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
The distance between Lyon and Italy is 713 km. The road distance is 1,016 km.
BlaBlaCar Bus operates a bus from Lyon - Gerland Bus Station to Roma, Autostazione Tiburtina once daily. Tickets cost €85–160 and the journey takes 14h 40m. Two other operators also service this route.