The average bus between Lyon and Mainz takes 11h 30m and the fastest bus takes 11h 19m. The bus service runs several times per day from Lyon to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Lyon and Mainz. The earliest departure is at 2:20 AM at night, and the last departure from Lyon is at 9:00 PM which arrives into Mainz at 11:09 AM. All services require a transfer at Frankfurt - Airport Bus Station and take an average of 11h 30m. The schedules shown below are for the next available departures.

11h 19m • 1 change

11h 19m • 1 change
Arrives next day

14h 9m • 1 change

11h 19m • 1 change

11h 19m • 1 change
Arrives next day

14h 9m • 1 change

11h 19m • 1 change

11h 19m • 1 change
Arrives next day

14h 9m • 1 change
Want to know about travelling from Lyon to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lyon to Mainz. However, there are services departing from Lyon station and arriving at Mainz station via Frankfurt - Airport Bus Station station. The journey, including transfers, takes approximately 11h 30m.
Lyon to Mainz bus services, operated by FlixBus, depart from Lyon - Gerland Bus Station.
Lyon to Mainz bus services, operated by FlixBus, arrive at Frankfurt - Airport Bus Station.
Book your Lyon to Mainz bus tickets online with FlixBus, DB Bus and BlaBlaCar Bus.
The distance between Lyon and Mainz is 535.9 km. The road distance is 795 km.
BlaBlaCar Bus operates a bus from Lyon - Gerland Bus Station to Frankfurt - Airport Bus Station every 4 hours. Tickets cost €65–120 and the journey takes 10h 50m. FlixBus also services this route twice daily.