The average bus between Lyon and Milan Cathedral takes 7h 8m and the fastest bus takes 6h 48m. The bus service runs several times per day from Lyon to Milan Cathedral. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Lyon and Milan Cathedral. The earliest departure is at 6:00 PM in the evening, and the last departure from Lyon is at 11:00 PM which arrives into Milan Cathedral at 5:48 AM. All services require a transfer at Milan Lampugnano and take an average of 7h 8m. The schedules shown below are for the next available departures.
Arrives next day

7h 1m • 1 change
Arrives next day

6h 48m • 1 change
Arrives next day

7h 1m • 1 change
Arrives next day

6h 48m • 1 change
Arrives next day

7h 1m • 1 change
Arrives next day

6h 48m • 1 change
Want to know about travelling from Lyon to Milan Cathedral? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lyon to Milan Cathedral. However, there are services departing from Lyon station and arriving at Milan Cathedral station via Milan Lampugnano. The journey, including transfers, takes approximately 7h 8m.
Lyon to Milan Cathedral bus services, operated by FlixBus, depart from Lyon Lyon Perrache Bus Station.
Lyon to Milan Cathedral bus services, operated by FlixBus, arrive at Milan Lampugnano station.
The distance between Lyon and Milan Cathedral is 339.4 km. The road distance is 448 km.
Itabus S.p.A. operates a bus from Lyon Lyon Perrache Bus Station to Milan Lampugnano once daily. Tickets cost €27–55 and the journey takes 6h 50m.