The average bus between Lyon and Pernes-les-Fontaines takes 6h 11m and the fastest bus takes 3h 50m. The bus service runs several times per day from Lyon to Pernes-les-Fontaines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a day between Lyon and Pernes-les-Fontaines. The earliest departure is at 5:20 AM in the morning, and the last departure from Lyon is at 11:50 PM which arrives into Pernes-les-Fontaines at 7:45 AM. All services require a transfer at Avignon and take an average of 6h 11m. The schedules shown below are for the next available departures.



4h 25m • 3 changes


4h 15m • 3 changes


6h 44m • 3 changes


5h 40m • 3 changes


4h 25m • 3 changes


4h 12m • 3 changes


6h 50m • 3 changes


5h 40m • 3 changes


4h 25m • 3 changes


4h 15m • 3 changes


6h 44m • 3 changes


5h 7m • 3 changes


4h 25m • 3 changes


4h 15m • 3 changes


4h 50m • 3 changes


5h 7m • 3 changes


3h 50m • 3 changes


5h 29m • 3 changes


6h 50m • 3 changes


5h 19m • 3 changesWant to know about travelling from Lyon to Pernes-les-Fontaines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lyon to Pernes-les-Fontaines. However, there are services departing from Lyon station and arriving at Pernes-les-Fontaines station via Avignon. The journey, including transfers, takes approximately 6h 11m.
Lyon to Pernes-les-Fontaines bus services, operated by FlixBus, depart from Lyon station.
Lyon to Pernes-les-Fontaines bus services, operated by FlixBus, arrive at Avignon station.
The distance between Lyon and Pernes-les-Fontaines is 195.3 km. The road distance is 249 km.
FlixBus operates a bus from Lyon to Avignon 4 times a day. Tickets cost €18–28 and the journey takes 2h 40m. BlaBlaCar Bus also services this route 5 times a day.