The average bus between Madrid and Brussels takes 21h 15m and the fastest bus takes 20h 56m. The bus service runs several times per day from Madrid to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Madrid and Brussels. The earliest departure is at 2:30 PM in the afternoon, and the last departure from Madrid is at 5:48 PM which arrives into Brussels at 3:15 PM. All services require a transfer at Estación Sur and take an average of 21h 15m. The schedules shown below are for the next available departures.
Arrives next day


21h • 2 changes
Arrives next day


21h 27m • 2 changes
Arrives next day


21h • 2 changes
Arrives next day


21h 27m • 2 changes
Arrives next day


21h • 2 changes
Arrives next day


21h 27m • 2 changes
Arrives next day


20h 56m • 2 changes
Arrives next day


21h 41m • 2 changes
Want to know about travelling from Madrid to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Madrid to Brussels. However, there are services departing from Madrid station and arriving at Brussels station via Paris - Bercy-Seine Bus Station station. The journey, including transfers, takes approximately 21h 15m.
Madrid to Brussels bus services, operated by Empresa Municipal de Transportes, depart from Estación Sur de Autobuses station.
Madrid to Brussels bus services, operated by Empresa Municipal de Transportes, arrive at Brussels - Midi Train Station.
The distance between Madrid and Brussels is 1,315.2 km. The road distance is 1,560 km.
You can take a bus from Callao to Brussels - Midi Train Station via Estación Sur, Estación Sur de Autobuses, and Paris - Bercy-Seine Bus Station in around 21h 18m.