The average bus between Madrid and Brussels takes 22h 25m and the fastest bus takes 21h. The bus service runs several times per day from Madrid to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Madrid and Brussels. The earliest departure is at 2:30 PM in the afternoon, and the last departure from Madrid is at 11:59 PM which arrives into Brussels at 11:30 AM. All services require a transfer at Estación Sur and take an average of 22h 25m. The schedules shown below are for the next available departures.
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21h 27m • 2 changesArrives next day


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21h 27m • 2 changesArrives next day


22h 13m • 2 changesWant to know about travelling from Madrid to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Madrid to Brussels. However, there are services departing from Madrid station and arriving at Brussels station via Paris - Bercy-Seine Bus Station station. The journey, including transfers, takes approximately 22h 25m.
Madrid to Brussels bus services, operated by Empresa Municipal de Transportes, depart from Estación Sur de Autobuses station.
Madrid to Brussels bus services, operated by Empresa Municipal de Transportes, arrive at Brussels - Midi Train Station.
The distance between Madrid and Brussels is 1,315.2 km. The road distance is 1,561 km.
You can take a bus from Callao to Brussels - Midi Train Station via Estación Sur, Estación Sur de Autobuses, and Paris - Bercy-Seine Bus Station in around 22h 39m.