The average bus between Madrid (Station) and Santander takes 5h 49m and the fastest bus takes 5h 36m. The bus service runs several times per day from Madrid (Station) to Santander. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Madrid (Station) and Santander. The earliest departure is at 12:15 AM at night, and the last departure from Madrid (Station) is at 11:55 PM which arrives into Santander at 6:30 AM. All services require a transfer, and take on average 5h 49m. The schedules shown below are for the next available departures.

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5h 36m • 1 changeWant to know about travelling from Madrid (Station) to Santander? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Madrid (Station) to Santander. However, there are services departing from Madrid (Station) station and arriving at Santander station via Estación de autobuses de Santander. The journey, including transfers, takes approximately 5h 49m.
Madrid (Station) to Santander bus services, operated by Consorcio de Transportes de Madrid, depart from Madrid, Avenida de América station.
Madrid (Station) to Santander bus services, operated by Consorcio de Transportes de Madrid, arrive at Estación de autobuses de Santander station.
The distance between Madrid (Station) and Santander is 335.7 km. The road distance is 410 km.
ALSA operates a bus from Madrid, Avenida de América to Estación de autobuses de Santander every 4 hours. Tickets cost €30–55 and the journey takes 5h 30m.