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Madrid to Palermo buses

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Trip Overview

The bus between Madrid and Palermo takes 2d 15h. The bus runs, on average, 5 times per week from Madrid to Palermo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 15h
Duration
3,235 km
Distance
€344
Average price
5 times a week
Frequency

Madrid to Palermo bus times

Buses run 5 times a week between Madrid and Palermo. The service departs Madrid at 6:05 PM in the evening, which arrives into Palermo at 11:00:00. All services require a transfer, and take on average 2d 15h. The schedules shown below are for the next available departures.

Departing Monday, November 2, 2026

  •  → 

    Arrives +3 days

    FlixBusFlixBus2d 15h • 1 change

Departing Tuesday, November 3, 2026

  •  → 

    Arrives +3 days

    FlixBusFlixBus2d 15h • 1 change

Departing Wednesday, November 4, 2026

  •  → 

    Arrives +3 days

    FlixBusFlixBus2d 15h • 1 change

Departing Thursday, November 5, 2026

  •  → 

    Arrives +3 days

    FlixBusFlixBus2d 15h • 1 change

Departing Friday, November 6, 2026

  •  → 

    Arrives +3 days

    FlixBusFlixBus2d 15h • 1 change

Frequently asked questions

Want to know about travelling from Madrid to Palermo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Madrid to Palermo.ExpandLaunch map view
  • Distance: 3,234.9 km
  • Duration: 2d 15h

What companies run services between Madrid, Spain and Palermo, Italy?

You can take a bus from Madrid to Palermo via Milano, Autostazione Lampugnano in around 46h.

Operators