The bus between Madrid and Santa Cruz de la Sierra takes 10h 25m. The bus runs, on average, 3 times per week from Madrid to Santa Cruz de la Sierra. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a week between Madrid and Santa Cruz de la Sierra. The earliest departure is at 2:40 AM at night, and the last departure from Madrid is at 2:40 AM which arrives into Santa Cruz de la Sierra at 1:05 PM. All services require a transfer, and take on average 10h 25m. The schedules shown below are for the next available departures.
Want to know about travelling from Madrid to Santa Cruz de la Sierra? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Madrid to Santa Cruz de la Sierra. However, there are services departing from Madrid station and arriving at Santa Cruz de la Sierra station via Trujillo. The journey, including transfers, takes approximately 10h 25m.
Madrid to Santa Cruz de la Sierra bus services, operated by Interbus, depart from Madrid Estación Sur de Autobuses station.
Madrid to Santa Cruz de la Sierra bus services, operated by Interbus, arrive at Trujillo station.
The distance between Madrid and Santa Cruz de la Sierra is 218.8 km. The road distance is 276 km.
Interbus operates a bus from Madrid Estación Sur de Autobuses to Trujillo 4 times a week. Tickets cost €26–50 and the journey takes 3h 5m.
