The average bus between Madrid and Santa Fe takes 6h 21m and the fastest bus takes 5h 15m. The bus service runs several times per day from Madrid to Santa Fe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Madrid and Santa Fe. The earliest departure is at 1:30 AM at night, and the last departure from Madrid is at 11:30 PM which arrives into Santa Fe at 6:10 AM. All services require a transfer, and take on average 6h 21m. The schedules shown below are for the next available departures.

5h 55m • 1 change

5h 45m • 1 change
Arrives next day

6h 40m • 1 change

6h 40m • 1 change

5h 55m • 1 change

5h 45m • 1 change
Arrives next day

6h 40m • 1 change

6h 40m • 1 change

5h 55m • 1 change

5h 45m • 1 change
Arrives next day

6h 40m • 1 change
Want to know about travelling from Madrid to Santa Fe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Madrid to Santa Fe. However, there are services departing from Madrid station and arriving at Santa Fe station via Granada Estación de Autobuses. The journey, including transfers, takes approximately 6h 21m.
Madrid to Santa Fe bus services, operated by ALSA, depart from Estación Sur de Autobuses station.
Madrid to Santa Fe bus services, operated by ALSA, arrive at Granada Estación de Autobuses station.
The distance between Madrid and Santa Fe is 358.9 km. The road distance is 421 km.
ALSA operates a bus from Estación Sur de Autobuses to Granada Estación de Autobuses every 3 hours. Tickets cost €30–50 and the journey takes 5h.