The average bus between Madrid and Santillana del Mar takes 7h 23m and the fastest bus takes 5h 55m. The bus service runs several times per day from Madrid to Santillana del Mar. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Madrid and Santillana del Mar. The earliest departure is at 12:30 AM at night, and the last departure from Madrid is at 4:30 PM which arrives into Santillana del Mar at 10:25 PM. All services require a transfer, and take on average 7h 23m. The schedules shown below are for the next available departures.

8h 40m • 1 change

7h 25m • 1 change

6h 55m • 1 change

5h 55m • 1 change

8h 40m • 1 change

7h 25m • 1 change

6h 55m • 1 change

5h 55m • 1 change

10h 55m • 1 change

7h 25m • 1 change

6h 55m • 1 change

5h 55m • 1 change

10h 55m • 1 change

7h 25m • 1 change

6h 55m • 1 change

5h 55m • 1 change
Want to know about travelling from Madrid to Santillana del Mar? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Madrid to Santillana del Mar. However, there are services departing from Madrid station and arriving at Santillana del Mar station via Torrelavega. The journey, including transfers, takes approximately 7h 23m.
Madrid to Santillana del Mar bus services, operated by ALSA, depart from Madrid, Avenida de América station.
Madrid to Santillana del Mar bus services, operated by ALSA, arrive at Torrelavega station.
Book your Madrid to Santillana del Mar bus tickets online with ALSA and Autobuses La Cantábrica.
The distance between Madrid and Santillana del Mar is 332.4 km. The road distance is 387 km.
ALSA operates a bus from Madrid, Avenida de América to Torrelavega every 4 hours. Tickets cost €30–45 and the journey takes 5h 10m.