The average bus between Madrid and Sestao takes 5h 41m and the fastest bus takes 5h 15m. There is a bus service every few hours from Madrid to Sestao. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 2 hours between Madrid and Sestao. The earliest departure is at 2:00 AM at night, and the last departure from Madrid is at 5:30 PM which arrives into Sestao at 11:16 PM. All services require a transfer at Bilbao Intermodal and take an average of 5h 41m. The schedules shown below are for the next available departures.

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Want to know about travelling from Madrid to Sestao? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Madrid to Sestao. However, there are services departing from Madrid station and arriving at Sestao station via Bilbao Intermodal. The journey, including transfers, takes approximately 5h 41m.
Madrid to Sestao bus services, operated by ALSA, depart from Madrid, Avenida de América station.
Madrid to Sestao bus services, operated by ALSA, arrive at Bilbao Intermodal station.
The distance between Madrid and Sestao is 326.8 km. The road distance is 407 km.
ALSA operates a bus from Madrid, Avenida de América to Bilbao Intermodal hourly. Tickets cost €30–65 and the journey takes 4h 10m.