Maine to Hyannis Buses

Maine to Hyannis buses

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Trip Overview

The average bus between Maine and Hyannis takes 5h 37m and the fastest bus takes 4h 42m. The bus service runs several times per day from Maine to Hyannis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 37m
Duration: 181 mi
Distance: $61
Average price: Every 2 hours
Frequency

Bus

best

Take the bus from Portland, ME to Boston, MA - South Stationbus Portland / ...
Take the bus from Boston South Buses to Hyannis Transportation Centerbus Hyannis - South Shore to Logan Airport

5h 4m

$50–84

Maine to Hyannis bus times

Buses run every 2 hours between Maine and Hyannis. The earliest departure is at 5:33 AM in the morning, and the last departure from Maine is at 10:15 PM which arrives into Hyannis at 8:15 AM. All services require a transfer at Portland, ME and take an average of 5h 37m. The schedules shown below are for the next available departures.

Departing Sunday, October 11, 2026

12:20 PM → 6:15 PM
5h 55m • 2 changes
1:20 PM → 7:15 PM
5h 55m • 2 changes
2:20 PM → 8:15 PM
5h 55m • 2 changes
4:20 PM → 9:15 PM
4h 55m • 2 changes
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Departing Monday, October 12, 2026

5:33 AM → 10:15 AM
4h 42m • 2 changes
6:50 AM → 12:15 PM
5h 25m • 2 changes
8:15 AM → 1:15 PM
5h • 2 changes
8:55 AM → 2:15 PM
5h 20m • 2 changes
Show more

Departing Tuesday, October 13, 2026

5:33 AM → 10:15 AM
4h 42m • 2 changes
6:50 AM → 12:15 PM
5h 25m • 2 changes
8:15 AM → 1:15 PM
5h • 2 changes
8:55 AM → 2:15 PM
5h 20m • 2 changes
Show more

Departing Wednesday, October 14, 2026

5:33 AM → 10:15 AM
4h 42m • 2 changes
6:50 AM → 12:15 PM
5h 25m • 2 changes
8:15 AM → 1:15 PM
5h • 2 changes
8:55 AM → 2:15 PM
5h 20m • 2 changes
Show more

Departing Thursday, October 15, 2026

5:33 AM → 10:15 AM
4h 42m • 2 changes
6:50 AM → 12:15 PM
5h 25m • 2 changes
8:15 AM → 1:15 PM
5h • 2 changes

Frequently asked questions

Want to know about travelling from Maine to Hyannis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Trip Overview

Bus